It is generally a good idea to build up the four foundation piles roughly evenly. If one foundation pile has more than a couple more cards in it than the other foundation piles, the foundation cards may not be available to be used in the tableau for building sequences, moving cards, and uncovering the face-down cards.
Klondike is one of the few solitaire games where cards may be taken off the foundation and placed on the tableau, so take advantage of it. (Although some say this is not a valid rule for any form of Klondike, most allow it.)
Creating a gap, and getting the face-down cards uncovered and available for play is usually a good move in Klondike Solitaire.